Efficacy of 1, 5, and 20 mg oral sildenafil in the treatment of adults with pulmonary arterial hypertension: a randomized, double-blind study with open-label extension

Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects of sildenafil.

Indexing Status

Choose an option Alt text (alternative text) helps when people can’t see the image or when it doesn’t load. Aim for 1-2 sentences that describe the subject, setting, or actions. This is used for ornamental sildenafil 50 mg tab images, like borders or watermarks. This alt text was created automatically and may be inaccurate. Downloading alt text AI model (0 of 0 MB) Automatic alt text Create alt text automaticallyDeleteDownload Suggests descriptions to help people who can’t see the image or when the image doesn’t load.

The International Index of Erectile Function

Runs locally on your device so your data stays private. Alt text editor Show alt text editor right away when adding an image Helps you make sure all your images have alt text. Pronunciation: sil-DEN-a-fil Generic name: sildenafil Brand names: Revatio, Viagra, Vybrique Dosage form: tablets (20 mg; 25 mg, 50 mg, 100 mg), injection (10 mg/12.5 mL), oral suspension (10 mg/mL), oral film (25 mg, 50 mg, 75 mg, 100 mg) Drug classes: Agents for pulmonary hypertension, Impotence medications Sildenafil is used to treat erectile dysfunction (ED) in adult men or pulmonary arterial hypertension (PAH) in adults and children, depending on the brand or formulation. Sildenafil tablets (25 mg, 50 mg, 100 mg; Viagra, generic) and sildenafil oral film (25 mg, 50 mg, 75 mg, 100 mg; Vybrique) are used for ED. Sildenafil tablets (20 mg; Revatio, generic), sildenafil oral suspension (Revatio, generic), and sildenafil injection (Revatio, generic) are used for PAH.

Similar content being viewed by others

Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor, which breaks down cyclic GMP and enhances nitric oxide (NO) -mediated smooth muscle relaxation. In erectile dysfunction (ED), this increases blood flow to penile tissue, facilitating an erection. In pulmonary arterial hypertension (PAH), it dilates pulmonary vessels by the same mechanism, reducing pulmonary blood pressure and improving exercise capacity. Sildenafil first gained FDA approval on March 27, 1998. Do not take sildenafil if you are also using a nitrate drug for chest pain or heart problems, including nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and some recreational drugs such as "poppers". Have allergies to sildenafil, Viagra, Revatio, Vybrique, or any of the ingredients in the sildenafil formulation you are taking Take other medicines for pulmonary arterial hypertension, such as riociguat (Adempas) Take other medicines

for pulmonary arterial hypertension, such as riociguat (Adempas) Take other medicines that lower your blood pressure, such

What to avoid

Physicians who prescribe sildenafil should do so only after a comprehensive work-up (history and physical examination, with diagnostic tests if indicated) has been completed. Oral sildenafil in the treatment of erectile dysfunction Research Question: Research Question: Funding: Funding: Year Study Began: Year Study Began: Year Study Published: Year Study Published: Study Location: Study Location: Who Was Studied: Who Was Studied: Who Was Excluded: Who Was Excluded: Patients: Patients: Study Overview: Study Overview: Study Interventions: Study Interventions: Follow-up: Follow-up: Endpoints: Endpoints: Criticism and Limitations: Criticism and Limitations: Other Relevant Studies and Information: Other Relevant Studies and Information: Summary and Implications: Summary and Implications: References References Other Relevant Studies and Information: Other Relevant Studies and Information: This chapter summarizes the results of a landmark trial comparing different doses of oral sildenafil versus placebo to treat erectile dysfunction. Patients received either an identical placebo or 25- mg, 50-mg, or 100-mg tablets of sildenafil to be taken approximately one hour before planned sexual activity (but not more than once daily) for 24 weeks. Higher doses of sildenafil resulted in higher mean score for frequency of penetration and maintenance of erection, which were also consistently better than placebo. The most common side effects were headaches, flushing, dyspepsia, rhinitis, and visual disturbances.

Effects of phosphodiesterase type 5 inhibitors on choroid and ocular vasculature: a literature review

This study established sildenafil as an effective, reasonably well-tolerated treatment for men with erectile dysfunction of varying etiologies. Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways: Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account. Choose this option to get remote access when outside your institution.

Professional resources

Shibboleth/Open Athens technology is used to provide single sign-on between your institution's website and Oxford Academic. Select your institution from the list provided, which will take you to your institution's website to sign in. When on the institution site, please women sildenafil use the credentials provided by your institution. Do not use an Oxford Academic personal account. Following successful sign in, you will be returned to Oxford Academic. as nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and some recreational drugs that also contain nitrates, such as "poppers".

• Patients with heart conditions should consult a cardiologist before use.
• Sildenafil may cause a temporary drop in blood pressure.
• Do not use sildenafil if you have a history of stroke or heart attack.

To make sure sildenafil is safe for you, tell your healthcare provider about all your medical conditions, including if you

have: Or have had heart problems such as a heart attack, irregular heartbeat, angina, chest pain, narrowing of the aortic valve,

Sildenafil Citrate 20 mg/mL, Oral Paste, 60mL Syringe

Tell all your healthcare providers that you take sildenafil. If you need emergency medical care for a heart problem, it will be important for your healthcare provider to know when you last took sildenafil. Stop sexual activity and get medical help right away if you get symptoms such as chest pain, dizziness, or nausea during sex. Sexual activity can put an extra strain on your heart, especially if your heart is already weak from a heart attack or heart disease. Sildenafil does not protect you or your partner from getting sexually transmitted diseases, including Human Immunodeficiency Virus (HIV). or heart failure Had heart surgery within the last 6 months Low blood pressure, or high blood pressure that is not

• Sildenafil can improve exercise capacity in pulmonary hypertension patients.
• Regular monitoring may be required for long-term use.
• Be aware of potential side effects related to blood pressure changes.

controlled A physical deformity of the penis (such as Peyronie's disease) Been told you should not have sexual intercourse for health

In case of emergency/overdose

Taking sildenafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure. Some medicines can cause unwanted or dangerous effects when used with sildenafil. Tell your doctor about all your current medicines, especially riociguat (Adempas). The most common side effects of sildenafil tablets for ED are: Abnormal vision, such as changes in color vision (such as having a blue color tinge) andblurred vision The most common side effects of sildenafil oral film for ED are: Abnormal vision, such as changes in color and blurred vision The most common side effects of sildenafil tablets/ oral suspension, and injection for PAH are: Sildenafil can cause the following serious side effects. If you have an erection that lasts more than 4 hours, get medical help right away.

Common Side Effects

If it is not treated right away, priapism can permanently damage your penis. Sildenafil can decrease blood flow to the optic nerve of the eye, causing sudden vision loss. This has occurred in a small number of people taking sildenafil, most of whom also had heart disease, diabetes, high blood pressure, high cholesterol, or certain pre-existing eye problems, and in those who smoked or were over 50 years old. Sudden vision loss in one or both eyes can be a sign of a serious eye problem called non-arteritic anterior ischemic optic neuropathy (NAION). Stop taking sildenafil and call your healthcare provider right away if you havesudden vision loss in one or both eyes.

Sildenafil Tablets or Oral Suspension for PAH

Some people may also have ringing in their ears sildenafil citrate 120 mg (tinnitus) or dizziness. If you have these symptoms, stop taking sildenafil and contact a doctor right away. In addition, heart attack, stroke, irregular heartbeats, and death have happened rarely in people taking sildenafil. Most, but not all, of these people had heart problems before taking this medicine. It is not known if sildenafil caused these problems. reasons and you are a male Had an erection that lasted for more than 4 hours Problems with your blood cells,

• Some men may experience minor flushing after taking sildenafil.
• If an adverse reaction occurs, stop medication and contact your doctor.
• Be aware of possible symptoms like sudden vision loss.

such as sickle cell anemia, multiple myeloma, or leukemia Retinitis pigmentosa, a rare genetic (runs in families) eye disease Ever had

Access options

If your institution is not listed or you cannot sign in to your institution's website, please contact your librarian or administrator. Enter your library card number to sign in. If you cannot sign in, please contact your librarian. Society member access to a journal is achieved in one of the following ways: Many societies offer single sign-on between the society website and Oxford Academic. If you see "Sign in through society site" in the sign in pane within a journal: When on the society site, please use the credentials provided by that society.

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:

If you do not have a society account or have forgotten your username or password, please contact your society. Some societies use Oxford Academic personal accounts to provide access to their members. A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions. Click the account icon in the top right to: View your signed in personal account and access account management features. View the institutional accounts that are providing access.

Recreational use

Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian. For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more. severe vision loss, including an eye problem called non-arteritic anterior ischemic optic neuropathy (NAION) Kidney problems or are having kidney dialysis

Are pregnant or intending to become pregnant (for patients with PAH) Are breastfeeding or intending to breastfeed (for patients with PAH).

What special precautions should I follow?

Sildenafil may cause low blood pressure, which may cause you to feel faint or dizzy. Lie down if you feel faint or dizzy. Tell your doctor if you get more short of breath after you start sildenafil. More shortness of breath than usual may be due to your underlying medical condition. Do not take Viagra while also taking Revatio.