Efficacy and safety of dapoxetine in men with premature ejaculation and concomitant erectile dysfunction treated with a phosphodiesterase type 5 inhibitor: randomized, placebo-controlled, phase III study

Priligy is suitable for men between the ages of 18 to 64 who are experiencing PE.

What’s New in 2025 2026: Behavioral Therapy, Combinations, and Comparative Studies

The patients were also assessed with global impression of change (GIC) question for the treatment satisfaction and the side effects were recorded. The study was completed with 53 patients (53/74, 71.62%). Mean age of the patients was 45.32 ± 10.05 years. At the end of the 4-week treatment period, the geometric mean IELT of the patients significantly increased (from 22.72 ± 15.16 to 68.25 ± 82.33 s; p < 0.001). Similarly, significant improvements were observed in the mean PEP index score (0.86 ± 0.72 vs.

Acquired PE

2.36 ± 1.13; p < 0.001) and mean IIEF-EF domain score (13.17 ± 3.33 vs. 24.60 ± 3.96; p < 0.001). According to the GIC results, 81.13% of the patients were satisfied with the treatment. Non-serious adverse events occurred in 10 patients (18.87%) and 4 (7.55%) of these patients dropped out of the treatment. The most common adverse events were headache, palpitation, and flushing. It is available in strengths of 30mg and 60mg tablets, you start on a 30mg dose, increasing to 60mg only if your doctor thinks that it is appropriate for you.

PE can mean different things to different men, so our doctors would need to understand how this affects you before deciding if it is suitable for you.

Priligy has been shown to improve sexual satisfaction in men who have PE, helping you to last up to 3 times longer1.

How do I take Priligy, and how often?

The dapoxetine/sildenafil combination therapy significantly improves the IELT values and patient reported outcome measures of PE patients who also suffer from ED. Although several side effects were reported, these were mild and transient. This is a preview of subscription content, access via your institution Receive 12 print issues and online access Instant access to the full article PDF. Prices may be subject to local taxes which are calculated during checkout Serefoglu EC, McMahon CG, Waldinger MD, Althof SE, Shindel A, Adaikan G, et al. An evidence-based unified definition of lifelong and acquired premature ejaculation: report of the Second International Society for Sexual Medicine Ad Hoc Committee for the Definition of Premature Ejaculation.

Other Literature Sources

Patrick DL, Althof SE, Pryor JL, Rosen R, Rowland DL, Ho KF, et al. Premature ejaculation: an observational study of men and their partners. An update of the International Society of Sexual Medicine’s Guidelines for the Diagnosis and Treatment of Premature Ejaculation (PE). Efficacy of dapoxetine for the treatment of premature ejaculation: a meta-analysis of randomized clinical trials on intravaginal ejaculatory latency time, patient-reported outcomes, and adverse events. Park HJ, Park NC, Kim TN, Baek SR, Lee KM, Choe S. Other non-medical self-help techniques in combination with treatment may give you the best results.

Access options

The authors would like to thank Neutec Ar-Ge San & Tic AS Clinical Research Department for their cooperation. This study has been sponsored by Neutec Ar-Ge San & Tic AS (Turkey). The authors declare that they have no conflict of interest. Publisher’s note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Efficacy and safety of dapoxetine/sildenafil combination tablets in the treatment of men with premature ejaculation and concomitant erectile dysfunction—DAP-SPEED Study.

What Is the Role of Ejaculation Latency in the Diagnosis of Premature Ejaculation and Does the Ejaculation Latency Threshold Matter?

What Is the Role of Ejaculation Latency in the Diagnosis of Premature Ejaculation and Does the Ejaculation Latency Threshold Matter? Conservative Non-surgical Options for Erectile Dysfunction Current Urology Reports (2023) The role of tyrosine hydroxylase within dapoxetine-assisted therapy against premature ejaculation Molecular Biology Reports (2023) Current and emerging treatment options for premature ejaculation Nature Reviews Urology (2022) Redefining a sexual medicine paradigm: subclinical premature ejaculation as a new taxonomic entity Nature Reviews Urology (2021) Priligy is a prescription treatment if you are male and experiencing premature ejaculation (PE), which can affect you at any age. It contains the active ingredient Dapoxetine, a type of medicine called an SSRI, originally developed to treat depression but then found to be effective for treating PE. Priligy increases the time it takes to ejaculate, can improve control over ejaculation and therefore reduces the frustration and anxiety you feel when experiencing PE. Unlike the SSRI medicines used to treat depression, it is short-acting and works more quickly, so you only take it when it is needed. Priligy is a type of medicine known as selective serotonin reuptake inhibitor (SSRI).

What are the side effects of dapoxetine (Priligy)?

Dapoxetine, when taken along with sildenafil, may lower your blood pressure, possibly upon standing. Please consult your doctor before taking these two medicines together. Premature ejaculation (PE) and erectile dysfunction (ED) are the most prevalent sexual disorders in men. ED is commonly reported among patients with PE. Although recent guidelines recommend to treat ED first in men with both PE and ED, this recommendation is not based on evidence and there are limited data about the efficacy and safety of dapoxetine/sildenafil combination therapy for these patients.

Priligy FAQs

The aim of this study is to evaluate the clinical efficacy and safety of the dapoxetine/sildenafil combination (Dapoxil® 30/50 mg film-coated tablet) in the treatment of patients with PE and concomitant ED. In a single-center, single-arm, open-label clinical study conducted between October 2016 and September 2017, 74 patients with lifelong or acquired PE and ED were included. All patients were instructed to record their intravaginal ejaculatory latency time (IELT) with a stopwatch for 4 weeks. After the screening, they were requested to complete Premature Ejaculation Diagnostic Tool (PEDT), Premature Ejaculation Profile (PEP), and International Index of Erectile Function-Erectile Function (IIEF-EF) questionnaires before the treatment. The patients received on demand Dapoxil® 1–3 h before sexual intercourse for the next 4 weeks (2 days a week and no more than once a day). It exerts its action by helping to maintain the body’s natural serotonin levels.

Serotonin is a natural hormone in our bodies which is responsible for many activities, including helping to regulate our mood and wellbeing.

Taking Priligy

Advances in understanding and treating premature ejaculation. Acceptance of and discontinuation rate from paroxetine treatment in patients with lifelong premature ejaculation. McMahon CG, Porst H. Oral agents for the treatment of premature ejaculation: review of efficacy and safety in the context of the recent International Society for Sexual Medicine criteria for lifelong premature ejaculation. Corona G, Rastrelli G, Limoncin E, Sforza A, Jannini EA, Maggi M.

Lifelong PE

Interplay between premature ejaculation and erectile dysfunction: a systematic review and meta-analysis. Uckert dapoxetine spain S, Oelke M, Stief CG, Andersson KE, Jonas U, Hedlund P. Immunohistochemical distribution of cAMP- and cGMP-phosphodiesterase (PDE) isoenzymes in the human prostate. Functional responses of isolated human seminal vesicle tissue to selective phosphodiesterase inhibitors. Comparative effectiveness and safety of oral phosphodiesterase type 5 inhibitors for erectile dysfunction: a systematic review and network meta-analysis. The involvement of serotonin in sexual arousal and ejaculation is not clearly understood but is believed to have a role because of the effectiveness of treatment with SSRIs such as Priligy. If you are a man between the ages of 18 and 64, have had repeated experiences of ejaculating within 2 minutes of penetration over the last 6 months, and this is causing you distress personally or within your relationship, then Priligy may be suitable for you.

INFORMATION ABOUT DAPOXETINE

Discontinuation of dapoxetine treatment in patients with premature ejaculation: a 2-year prospective observational study. Mondaini N, Fusco F, dapoxetine 60 mg buy online Cai T, Benemei S, Mirone V, Bartoletti R. Dapoxetine treatment in patients with lifelong premature ejaculation: the reasons of a “Waterloo”. Premature ejaculation and erectile dysfunction prevalence and attitudes in the Asia-Pacific region. AUA guideline on the pharmacologic management of premature ejaculation.

Statistical analysis

EAU guidelines on erectile dysfunction, premature ejaculation, penile curvature and priapism. Arnhem, The Netherlands: EAU Guidelines Office; 2018. Efficacy of phosphodiesterase-5 inhibitor in men with premature ejaculation: a new systematic review and meta-analysis. Men C, Yu L, Yuan H, Cui Y. Efficacy and safety of phosphodiesterase type 5 inhibitors on primary premature ejaculation in men receiving selective serotonin reuptake inhibitors therapy: a systematic review and meta-analysis. Our doctors will help you to understand if what you are experiencing is PE and whether treatment with Priligy is appropriate for you.

• Dapoxetine can improve confidence and sexual satisfaction.
• It is contraindicated in men with severe heart or liver conditions.
• The optimal dose varies; typically, 30 mg or 60 mg based on tolerance.
• Do not take dapoxetine with other SSRIs or serotonin drugs without medical advice.
• The onset of action is usually within 1-3 hours after intake.
• Dapoxetine is rapidly absorbed and eliminated from the body.

Priligy should be taken between 1 to 3 hours before you are expecting sexual activity.

• Dapoxetine is a quick-acting medication designed for on-demand use before sex.
• It is effective in delaying ejaculation and increasing satisfaction.
• The medication is generally safe when used as directed under medical supervision.
• It is important to consider psychological factors alongside medication treatment.
• Dapoxetine may be combined with counseling or therapy for better results.
• Discontinuing dapoxetine should be discussed with your doctor first.

The tablet should be swallowed whole with a full glass of water, with or without food.

How to Take Dapoxetine

Asimakopoulos AD, Miano R, Finazzi Agro E, Vespasiani G, Spera E. Does current scientific and clinical evidence support the use of phosphodiesterase type 5 inhibitors for the treatment of premature ejaculation? Turkish validation of the premature ejaculation diagnostic tool and its association with intravaginal ejaculatory latency time. The comparison of premature ejaculation assessment questionnaires and their sensitivity for the four premature ejaculation syndromes: results from the Turkish society of andrology sexual health survey. Patrick DL, Giuliano F, Ho KF, Gagnon DD, McNulty P, Rothman M.

Conservative Non-surgical Options for Erectile Dysfunction

The Premature Ejaculation Profile: validation of self-reported outcome measures for research and practice. Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A. The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. An empirical operationalization study of DSM-IV diagnostic criteria for premature ejaculation. A tutorial on pilot studies: the what, why and how.